We have written quite a bit about the side effects of statins such as atorvastatin (Lipitor), rosuvastatin (Crestor) and simvastatin (Zocor). Muscle side effects seem to be less common with Zetia than with the statin drugs, but Zetia may cause muscle problems. Within the past few years, FDA has approved new drugs to lower cholesterol. With so many drugs now available to lower cholesterol, people naturally would like to know about the benefits and risks of each. Join our daily email newsletter with breaking health news, prescription drug information, home remedies AND you'll get a copy of our brand new full-length health guide — for FREE! Probably the most troublesome side effect patients report on one of these drugs is muscle pain or weakness. 3, 2008). Unfortunately, it didn’t reduce the risk of dying from cardiovascular causes. The investigators note that many people stopped taking Vytorin or Zetia after they learned about this trial. In the meantime, keep in mind that Zetia may cause muscle pain itself. Can you shed any light on this? My doctor put me on Zetia and insists it can’t cause muscle pain since it is not absorbed into the blood stream. My doctor put me on Zetia and insists it can’t cause muscle pain since it is not absorbed into the blood stream. He was not the only one to see ezetimibe in a less positive light. I have problems taking statins. Terry Graedon, PhD, is a medical anthropologist and co-host of The People’s Pharmacy radio show, co-author of The People’s Pharmacy syndicated newspaper columns and numerous books, and co-founder of The People’s Pharmacy website. Terry is one of the country's leading authorities on the science behind folk remedies. There was a lot of hoopla recently about the drug Zetia. The unresolved question is whether they prevent atherosclerosis, heart attacks and strokes. Rashes, lesions, alterations in blood tests, liver problems, stomach pain, pancreas inflammation, nausea, depression, hair loss, gallstones and inflammation of the gall bladder have all been experienced. You can learn more about these medications from our interview with Dr. Steve Nissen about the GAUSS-3 trial of evolocumab and ezetimibe in people who have muscle pain on statins. As it turns out, Zetia may cause muscle problems, too. Can Zetia cause this? A. They lower cholesterol dramatically through a different mechanism from statins. They do not have data to show whether people who stopped taking Zetia had more heart attacks or strokes, so the jury is still out on that. Side effects of Zetia include: diarrhea, back pain, stomach or abdominal pain, numbness or tingly feeling, tired feeling, headache, dizziness, depressed mood, A pharmacist told me that the FDA hasn’t recalled it, so it must be all right. Evolocumab (Repatha) and alirocumab (Praluent) are PCSK9 inhibitors. It is Show 1031. Consequently, we expect that other patients might end up taking them. The study was funded by the two companies that make Zetia, Merck and Schering-Plough. A. Zetia (ezetimibe) and Vytorin (ezetimibe and simvastatin) lower cholesterol. We don’t know how the benefits and risks of PCSK9 inhibitors will play out over time. My doctor tells me that until more is known, I should continue taking the prescribed medicine. BS. Cardiologist Steven Nissen, MD, of the Cleveland Clinic said he was shocked by the results. He advised his colleagues not to prescribe Zetia except as a last resort. I still have muscle pain, cramps and tingling in my legs and feet. In the wake of the ENHANCE study that produced such disappointing results with Vytorin, the American College of Cardiology convened an expert panel to advise their colleagues. There should be no danger switching to simvastatin, since it has been shown to be effective at lowering cholesterol and reducing the risk of heart attacks in people with heart disease (Ursoniu et al, Pharmacological Research, online June 9, 2017). Learn about side effects, dosage, and more. These thought leaders suggest that doctors should stick with statin-type cholesterol-lowering drugs, which have a proven track record. My experience with Zetia Imagine walking to a friend’s dinner party. Scientists compared the thickness of the lining of the carotid arteries in the neck between people put on Vytorin and those on simvastatin (Kastelein et al, New England Journal of Medicine, Apr. I still have muscle pain, cramps and tingling in my legs and feet. Here are some of the other problems those taking Zetia have faced: allergic reactions including facial and throat swelling which may cause difficulty in breathing or swallowing. Muscle Pain on Zetia: Q. I have tried many statin drugs for cholesterol, but all gave me muscle pain and cramps. At this time, these pricey medications are considered appropriate for treating people with familial high cholesterol. That’s too bad, they say. Is it harmful to switch abruptly to another cholesterol-lowering medicine such as simvastatin? Sometimes, however, doctors find it hard to resist reaching into their toolbox for the newest thing that might help. It would be appropriate to discuss your treatment with your doctor to see if there is another approach that might suit you better. She is a Fellow of the Society of Applied Anthropology. Safeguards Before Taking Zetia. Vytorin lowered bad LDL cholesterol more than Zocor did but this did not lead to healthier arteries. Here is another question we got from a reader around that time: Q. I am alarmed by recent reports that Vytorin and Zetia are associated with plaque build-up in the carotid artery. Common side effects of ezetimibe include diarrhea, abdominal pain, back pain, joint pain, muscle aches… That increased their predicted risk of cardiovascular disease. Most of the studies about Zetia in which Merck and Schering have published the results covered periods of only 12 weeks not enough time for liver problems to develop in most patients. We're empowering you to make wise decisions about your own health, by providing you with essential health information about both medical and alternative treatment options. Dysphagia and stomach upset were the two main side effects I experienced with Zetia, at both 5mg and 10mg doses. A. I called my doctor, who told me to continue taking it, but if it’s not doing anything good for my high cholesterol, why bother? started zetia in January-no issues for a month-then the gas started -then explosive gas-running to bathroom 8-15 times a day not knowing what is was going to be. Can Zetia cause this? Q. I have tried many statin drugs for cholesterol, but all gave me muscle pain and cramps. About 60 percent of U.S. patients who are taking Zetia now receive the drug as part of Vytorin. Repatha has been shown to reduce the risk of heart attack and stroke (Sabatine et al, New England Journal of Medicine, May 4, 2017). Although Zetia works differently from statin cholesterol-lowering drugs such as Lipitor or Zocor, it is absorbed into the bloodstream. But the new two-year trial of 720 patients sheds doubt on whether it makes any sense for people battling cholesterol to take Vytorin versus Zocor alone, experts said. GAUSS-3 trial of evolocumab and ezetimibe. The study you heard about was called ENHANCE because the company hoped Vytorin would be better than Zocor (simvastatin) alone. But what about ezetimibe (Zetia)? Until there is more convincing data about Vytorin or Zetia, the cardiologists recommend using them only as a last resort.

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